tag:blogger.com,1999:blog-16789804.post5669659165631026925..comments2023-10-23T13:38:13.848-06:00Comments on The Scoop on Dan: Carfilzomib or Pomalidomide Anyone?dan pattersonhttp://www.blogger.com/profile/01422820512237999017noreply@blogger.comBlogger2125tag:blogger.com,1999:blog-16789804.post-25770968587758785082009-08-14T13:26:39.262-06:002009-08-14T13:26:39.262-06:00Hi Dan!
Glad that you were able to get BB and Rif...Hi Dan!<br /><br />Glad that you were able to get BB and Rifkin together on this topic. <br /><br />I'm not a hematologist / oncologist but I play one on TV and here's what I've gleaned about the two drugs.<br /><br />Carfilzomib is next-generation Velcade. It is stronger, has shown the ability to succeed in patients with Velcade-resistant disease, and is easy to tolerate. It is still in Phase III clinical trials but BB has been using it in his clinic and I'm sure between his efforts and Rifkin's, you'll be able to get it. Although have your doctors determined that you weren't responding to Velcade? Seems to me you may have been responding but you judged it wasn't work going through the relentless carpet bombing your system was taking from the other drugs?<br /><br />Pomalidomide is next-generation Revlimid, which itself is next-generation Thalidomide. Revlimid is more effective than Thalidomide and has fewer side effects. It DOES, however, suppress blood counts and makes it difficult to harvest cells, which is why BB doesn't use Revlimid until maintenance. Pomalidomide, similarly, has been shown to be successful in patients whose disease does not respond to Revlimid. It has been in Phase III trials and a lot of work is being done with it at Mayo. If you go to the Myeloma Hope blog that Don keeps on blogger, he has been in a Pomalidomide (aka CC-4047) trial for some time and it has been effective at managing his disease.<br /><br />The good news is both of these drugs have a track record of succeeding where previous drugs have failed. Especially if you are in "control" rather than "eradicate" mode, they might be just what the doctor ordered.<br /><br />Take care and keep us posted!!!<br /><br />Warmly,<br /><br />Nick (and Jill)Nickhttps://www.blogger.com/profile/09733312143898687572noreply@blogger.comtag:blogger.com,1999:blog-16789804.post-42022062558938133882009-08-11T23:37:44.324-06:002009-08-11T23:37:44.324-06:00Ouf! as we say in French (pronounced 'ooff'...Ouf! as we say in French (pronounced 'ooff' - a sigh of relief). That was a pretty good visit. And two new drugs for you on the horizon. Not bad for a MOnday. Keep it up! Bises, Sigun.sigunhttps://www.blogger.com/profile/11314253297860907914noreply@blogger.com